Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.30 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553104 | 0.79 | PRKCI (0.35) | RAB9ANPC1NPSR1MAPTLMNA | |
| SCHEMBL9747175 | 0.72 | PRKCI (0.42) | RAB9ANPC1NPSR1MAPTLMNA | |
| SCHEMBL10506114 | 0.69 | CYSLTR2 (0.33) | RAB9ANPC1NPSR1MAPTLMNA | |
| SCHEMBL2476525 | 0.68 | MAPT (0.39) | RAB9ANPC1NPSR1MAPTLMNA | |
| SCHEMBL481132 | 0.68 | PPARG (0.50) | MAPTLMNAPPARGPPARAALOX5 | |
| SCHEMBL30365671 | 0.68 | PPARG (0.50) | MAPTLMNAPPARGPPARAALOX5 | |
| SCHEMBL11822691 | 0.67 | L3MBTL1 (0.52) | RAB9ANPC1NPSR1LMNAALDH1A1 | |
| SCHEMBL10814683 | 0.67 | NCEH1 (0.41) | MAPTLMNAPPARGPPARAALOX5 | |
| SCHEMBL13924206 | 0.66 | ALOX5 (0.41) | MAPTLMNAALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL13116417 | 0.66 | RAB9A (0.39) | RAB9ANPC1NPSR1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |