Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 5/20 | 0.31 |
| ▸ | DRD3 | P35462 | 5/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553104 | 0.89 | PRKCI (0.35) | PRKCIRAB9ANPC1NPSR1MAPT | |
| SCHEMBL9739521 | 0.75 | PRKCI (0.56) | PRKCIALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL9739158 | 0.73 | PRKCI (0.42) | PRKCINPSR1ALDH1A1KDM4EHPGD | |
| SCHEMBL9740369 | 0.72 | RAB9A (0.37) | RAB9ANPC1NPSR1MAPTLMNA | |
| SCHEMBL9740854 | 0.72 | PRKCI (0.51) | PRKCIKDM4EHPGDPOLBALOX5 | |
| SCHEMBL9740799 | 0.70 | PRKCI (0.65) | PRKCIHPGDPOLBALOX5PTPN1 | |
| SCHEMBL9739383 | 0.70 | PPARA (0.61) | PPARGPPARA | |
| SCHEMBL9742145 | 0.69 | PRKCI (0.35) | PRKCIALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL9740473 | 0.68 | PPARA (0.56) | PRKCIPPARGPPARA | |
| SCHEMBL9739756 | 0.67 | PRKCI (0.56) | PRKCIMAPTLMNAHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |