SCHEMBL974230

SCHEMBL974230

Cn1cc(C(=O)Cl)c(C(F)(F)F)n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.57
POLB P06746 1/20 0.57
GAA P10253 1/20 0.55
STING1 Q86WV6 1/20 0.40
PSEN1 P49768 1/20 0.38
PSEN2 P49810 1/20 0.38
APH1B Q8WW43 1/20 0.38
NCSTN Q92542 1/20 0.38
APH1A Q96BI3 1/20 0.38
PSENEN Q9NZ42 1/20 0.38
NTRK1 P04629 1/20 0.36
KLKB1 P03952 1/20 0.35
BACE1 P56817 2/20 0.35
BACE2 Q9Y5Z0 2/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C19 P33261 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
DGAT1 O75907 1/20 0.34
IRAK4 Q9NWZ3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20448183 0.88 LMNA (0.46) LMNAPOLBGAASTING1PSEN1
SCHEMBL2342441 0.88 GAA (0.47) LMNAPOLBGAASTING1PSEN1
SCHEMBL19182678 0.84 GAA (0.56) LMNAPOLBGAASTING1PSEN1
SCHEMBL353314 0.84 GAA (0.56) LMNAPOLBGAASTING1PSEN1
SCHEMBL2445416 0.84 LMNA (0.41) LMNAPOLBGAAKDM4E
SCHEMBL13936345 0.84 POLB (0.58) LMNAPOLBGAASTING1PSEN1
SCHEMBL28114507 0.83 LMNA (0.62) LMNAPOLBGAASTING1NTRK1
SCHEMBL20679052 0.83 LMNA (0.55) LMNAPOLBGAASTING1PSEN1
SCHEMBL970933 0.82 GAA (0.55) LMNAPOLBGAASTING1PSEN1
SCHEMBL4556189 0.82 GAA (0.55) LMNAPOLBGAASTING1PSEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114957124-B 3- (trifluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof 浙江工业大学 2023-11-07 CN claimed
CN-115260174-A 5- (pyrazole-4-yl) -1,2, 4-oxadiazole substituted benzamide compounds and preparation method and application thereof 浙江工业大学 2022-11-01 CN claimed
CN-114957124-A 3- (trifluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof 浙江工业大学 2022-08-30 CN claimed
CN-103554026-B One group of 3-trifluoromethyl-4-formyl pyrazole compound QINGDAO AGRICULTURAL UNIVERSITY (CN) 2016-04-27 CN claimed
CN-103554026-A 3-trifluoromethyl-4-formyl pyrazole compounds UNIV QINGDAO AGRICULTURAL 2014-02-05 CN claimed
JP-11228567-A None JP disclosed
US-20250380697-A1 ISOXAZOLINE DERIVATIVE COMPOUND AND INSECTICIDAL COMPOSITION COMPRISING SAME KYUNG NONG CORPORATION (KR) 2025-12-18 US disclosed
WO-2024005548-A1 ISOXAZOLINE DERIVATIVE COMPOUND AND INSECTICIDAL COMPOSITION COMPRISING SAME 주식회사 경농 2024-01-04 WO disclosed
CN-114957124-B 3- (trifluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof 浙江工业大学 2023-11-07 CN disclosed
CN-114773327-B Preparation method of penthiopyrad intermediate 广东优康精细化工有限公司 2023-08-18 CN disclosed
CN-110903279-B Pyrazole compound, salt and application thereof 潍坊中农联合化工有限公司 2023-05-16 CN disclosed
CN-115260174-A 5- (pyrazole-4-yl) -1,2, 4-oxadiazole substituted benzamide compounds and preparation method and application thereof 浙江工业大学 2022-11-01 CN disclosed
US-5747518-A EFFECTIVE AGAINST CHEMICAL RESISTANT FUNGI; NONPHYTOTOXIC TO CROPS MITSUI TOATSU CHEMICALS, INC. (JP) 1998-05-05 US disclosed
EP-0824099-A1 Substituted carboxanilide derivative and plant disease control agent comprising same as active ingredient MITSUI TOATSU CHEMICALS, Inc. (JP) 1998-02-18 EP disclosed
EP-0623113-B1 PYRAZOLE CARBOXANILIDE FUNGICIDES MONSANTO CO (US) 1997-03-05 EP disclosed
EP-0737682-A1 Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1996-10-16 EP disclosed
EP-0623113-A1 PYRAZOLE CARBOXANILIDE FUNGICIDES. MONSANTO CO (US) 1994-11-09 EP disclosed
CN-1078234-A Pyrazole carboxanilide fungicide MONSANTO CO (US) 1993-11-10 CN disclosed
US-5223526-A For plants MONSANTO COMPANY (US) 1993-06-29 US disclosed
WO-1993011117-A1 PYRAZOLE CARBOXANILIDE FUNGICIDES MONSANTO COMPANY (US) 1993-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250380697-A1 ISOXAZOLINE DERIVATIVE COMPOUND AND INSECTICIDAL COMPOSITION COMPRISING SAME VIP, CASP7, CYP4X1 LMNA 3287/4885POLB 4559/4885GAA 4451/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.