Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CDC42 | P60953 | 1/20 | 0.42 |
| ▸ | RAC1 | P63000 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28062466 | 0.91 | LMNA (0.46) | MAPTCYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL30937976 | 0.84 | CYP3A4 (0.65) | MAPTCYP3A4MEN1KMT2APPARG | |
| SCHEMBL3484699 | 0.80 | NPC1 (0.49) | MAPTCYP3A4MEN1KMT2APPARG | |
| SCHEMBL3507498 | 0.79 | CYP3A4 (0.74) | MAPTCYP3A4MEN1KMT2APPARG | |
| SCHEMBL8397291 | 0.79 | NPC1 (0.47) | MAPTCYP3A4MEN1KMT2APPARG | |
| SCHEMBL68736 | 0.76 | CES2 (0.55) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4809737 | 0.76 | RAB9A (0.62) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11283361 | 0.76 | TDP1 (0.55) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL9726513 | 0.76 | RAB9A (0.66) | MAPTCYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL29757182 | 0.75 | CA1 (0.53) | MAPTCYP3A4MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236628-A1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-09-16 | — | — | EP | claimed |
| EP-0236628-B1 | INHIBITION OF THE 5-LIPOXYGENASE PATHWAY | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0236628-A1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4686231-A | 4,5-DIARYL-2-SUBSTITUTED-IMIDAZOLE | SMITHKLINE BECKMAN CORPORATION (US) | 1987-08-11 | — | — | US | disclosed |