Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 7/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9745279 | 0.85 | CACNA1B (0.47) | CACNA1BADORA3HIF1AMEN1CYP1A2 | |
| SCHEMBL9744269 | 0.84 | CACNA1C (0.65) | CACNA1BADORA3HIF1AMEN1CYP1A2 | |
| SCHEMBL9744281 | 0.84 | CACNA1C (0.65) | CACNA1BADORA3HIF1AMEN1CYP1A2 | |
| SCHEMBL9502243 | 0.81 | ADORA3 (0.73) | CACNA1BADORA3HIF1AMEN1CYP1A2 | |
| SCHEMBL9745148 | 0.80 | ADORA3 (0.48) | CACNA1BADORA3HIF1AMEN1CYP1A2 | |
| SCHEMBL10786311 | 0.78 | CACNA1B (0.56) | CACNA1BADORA3HIF1AMEN1CYP1A2 | |
| SCHEMBL9745156 | 0.77 | GAA (0.43) | HIF1AMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3026966 | 0.76 | ABCC1 (0.71) | CACNA1BADORA3HIF1AMEN1CYP1A2 | |
| SCHEMBL9744740 | 0.76 | CACNA1B (0.55) | CACNA1BADORA3 | |
| SCHEMBL3028393 | 0.74 | GAA (0.66) | ADORA3MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215250-B1 | 2-SUBSTITUTED-1,4-DIHYDROPYRIDINES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-30 | — | — | EP | disclosed |
| US-4845113-A | USEFUL IN RADICAL SCAVENGING THERAPY | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-07-04 | — | — | US | disclosed |
| EP-0215250-A1 | 2-Substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-25 | — | — | EP | disclosed |