SCHEMBL9745314

SCHEMBL9745314

CCCCOC(=O)CC(=O)c1cc(F)c(F)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.58
RECQL P46063 1/20 0.58
CYP1A2 P05177 2/20 0.53
CYP2C19 P33261 2/20 0.53
GAA P10253 2/20 0.45
HPGD P15428 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
LMNA P02545 2/20 0.44
ALDH1A1 P00352 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
MAPT P10636 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
ESR1 P03372 2/20 0.43
POLB P06746 1/20 0.42
APEX1 P27695 1/20 0.42
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
CYP2C9 P11712 1/20 0.41
TSHR P16473 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9219919 0.92 HTT (0.51) HTTRECQLCYP1A2CYP2C19GAA
SCHEMBL1241168 0.85 GAA (0.49) HTTRECQLCYP1A2CYP2C19GAA
SCHEMBL9244541 0.82 CYP1A2 (0.65) HTTRECQLCYP1A2CYP2C19GAA
SCHEMBL9186659 0.81 GAA (0.56) HTTRECQLCYP1A2CYP2C19GAA
SCHEMBL7843664 0.78 L3MBTL1 (0.45) HTTRECQLCYP1A2CYP2C19HPGD
SCHEMBL4714980 0.78 TDP1 (0.42) HTTRECQLCYP1A2CYP2C19GAA
SCHEMBL11666101 0.78 ALDH1A1 (0.40) HTTRECQLHPGDLMNAALDH1A1
SCHEMBL7009795 0.77 TDP1 (0.41) HTTRECQLCYP1A2CYP2C19GAA
SCHEMBL30680417 0.75 ALDH1A1 (0.42) HTTRECQLCYP1A2CYP2C19GAA
SCHEMBL9246288 0.75 CYP1A2 (0.56) HTTRECQLCYP1A2CYP2C19HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5093515-A Intermediate for quinolone carboxylic acid bactericide ASAHI GLASS COMPANY LTD. (JP) 1992-03-03 US disclosed
US-5068449-A FLUORINATED BENZOYL COMPOUNDS ASAHI GLASS COMPANY, LTD. (JP) 1991-11-26 US disclosed