Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | THPO | P40225 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10492355 | 0.78 | SMN1; SMN2 (0.40) | LMNAMAPTSMN1; SMN2CYP3A4HSD17B10 | |
| SCHEMBL439211 | 0.76 | PTGS2 (0.46) | PTGS2LMNAMAPTPTGS1CXCR1 | |
| SCHEMBL2037726 | 0.76 | PTGS2 (0.46) | PTGS2LMNAMAPTPTGS1CXCR1 | |
| SCHEMBL1518530 | 0.74 | PTGS2 (0.44) | PTGS2LMNAMAPTPTGS1CXCR1 | |
| SCHEMBL5209636 | 0.74 | PTGS2 (0.42) | PTGS2LMNACYP3A4HSD17B10THPO | |
| SCHEMBL702447 | 0.73 | TDP1 (0.61) | PTGS2LMNAMAPTPTGS1CXCR1 | |
| SCHEMBL9717408 | 0.73 | SMN1; SMN2 (0.47) | PTGS2LMNAMAPTPTGS1CXCR1 | |
| SCHEMBL7617096 | 0.73 | PTGS2 (0.47) | PTGS2LMNAMAPTPTGS1CXCR1 | |
| SCHEMBL5088282 | 0.73 | PTGS2 (0.43) | PTGS2LMNAMAPTPTGS1CXCR1 | |
| SCHEMBL10894082 | 0.73 | TDP1 (0.61) | PTGS2LMNAMAPTPTGS1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204285-B1 | IMIDAZOHETEROCYCLIC COMPOUNDS PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4725601-A | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0204285-A1 | Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-12-10 | — | — | EP | disclosed |