Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749113 | 0.87 | ABCB11 (0.54) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL10905343 | 0.85 | ABCB11 (0.46) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL9747697 | 0.85 | ABCB11 (0.46) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL9749157 | 0.84 | ABCB11 (0.59) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL10396917 | 0.82 | ABCB11 (0.44) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28420990 | 0.81 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL34411 | 0.80 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL14861906 | 0.80 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57092 | 0.79 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57090 | 0.79 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | claimed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | claimed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | claimed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | disclosed |
| US-4568695-A | ANTIINFLAMMATORY AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-02-04 | — | — | US | disclosed |