Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29054974 | 0.81 | MAPT (0.51) | LMNAALDH1A1MAPTGRM6PTK2B | |
| SCHEMBL9747962 | 0.81 | ABCB11 (0.47) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| SCHEMBL10714684 | 0.78 | PTGS1 (0.46) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| SCHEMBL10951413 | 0.76 | SRC (0.38) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| SCHEMBL10951422 | 0.76 | SRC (0.38) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| SCHEMBL10713921 | 0.75 | PTGS2 (0.43) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| SCHEMBL11443283 | 0.75 | CYP1A2 (0.44) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| Amfenac SCHEMBL24249 | 0.74 | ABCB11 (0.78) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| Amfenac SCHEMBL30777846 | 0.74 | ABCB11 (0.78) | LMNAPTGS2ABCB11PTGS1ADORA1 | |
| SCHEMBL7487247 | 0.74 | ATM (0.50) | LMNAPTGS2PTGS1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | claimed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | claimed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | claimed |