Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 3/20 | 0.43 |
| ▸ | FNTB | P49356 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 6/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531120 | 0.84 | FNTA (0.59) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL16261172 | 0.76 | SSTR4 (0.46) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL16261173 | 0.75 | ALDH1A1 (0.48) | ALDH1A1GAAHPGDNPSR1RXFP1 | |
| SCHEMBL7449672 | 0.72 | BAZ2B (0.46) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL21696287 | 0.72 | TP53 (0.49) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL9531363 | 0.72 | HTR3A (0.56) | ALDH1A1 | |
| SCHEMBL21696256 | 0.71 | SSTR4 (0.40) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL8404415 | 0.71 | KDM4E (0.43) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL28448668 | 0.69 | MAPT (0.48) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL9533942 | 0.69 | BAZ2B (0.42) | KDM4EALDH1A1GLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254584-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1992-10-07 | — | — | EP | disclosed |
| US-4822795-A | Pharmaceutically useful esters and amides | BEECHAM GROPUP P.L.C. (GB) | 1989-04-18 | — | — | US | disclosed |
| EP-0254584-A2 | Azabicyclic compounds, process for their preparation, and their pharmaceutical use | BEECHAM GROUP PLC (GB) | 1988-01-27 | — | — | EP | disclosed |