Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | LTA4H | P09960 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1771825 | 0.80 | ALDH1A1 (0.79) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL23610361 | 0.78 | ALDH1A1 (0.83) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL10207991 | 0.78 | GAA (0.51) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6225037 | 0.76 | EIF4E (0.46) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL172279 | 0.74 | ALDH1A1 (0.70) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL44869 | 0.74 | ALDH1A1 (1.00) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL130198 | 0.74 | ALDH1A1 (0.69) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL10719025 | 0.74 | ALDH1A1 (0.61) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL13714728 | 0.73 | AR (0.51) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL29152977 | 0.73 | NPC1 (0.60) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57177060-A | — | — | None | — | — | JP | disclosed |
| CN-117486872-A | Mechanical ball milling synthesis method of aminothiazole compound | 浙江工业大学 | 2024-02-02 | — | — | CN | disclosed |
| US-11453663-B2 | Substituted propanamides as inhibitors of nucleases | MASARYKOVA UNIVERZITA (CZ) | 2022-09-27 | — | — | US | disclosed |
| US-20220073507-A1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2022-03-10 | — | — | US | disclosed |
| US-20210205275-A1 | NEUROPROTECTIVE COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2021-07-08 | — | — | US | disclosed |
| CN-112351983-A | Substituted propionamides as inhibitors of nucleases | 马萨里克大学 | 2021-02-09 | — | — | CN | disclosed |
| EP-3556756-B1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | UNIV MASARYKOVA (CZ) | 2020-10-07 | — | — | EP | disclosed |
| EP-3556756-B1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | UNIV MASARYKOVA (CZ) | 2020-10-07 | — | — | EP | disclosed |
| WO-2019201867-A1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019201867-A1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |
| EP-3556756-A1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | Masarykova univerzita (CZ) | 2019-10-23 | — | — | EP | disclosed |
| EP-3556756-A1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | Masarykova univerzita (CZ) | 2019-10-23 | — | — | EP | disclosed |
| US-5112362-A | NAVY DYE MIXTURES OF AZO DISPERSE DYES FOR POLYESTER | BASF AKTIENGESELLSCHAFT (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0450434-A2 | Marine blue dyestuff mixtures | BASF Aktiengesellschaft (DE) | 1991-10-09 | — | — | EP | disclosed |
| US-4841036-A | COLORFAST, HEAT RESISTANCE | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1989-06-20 | — | — | US | disclosed |
| JP-S57177060-A | DISAZO DYE FOR POLYESTER FIBER | MITSUBISHI CHEM IND LTD | 1982-10-30 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220073507-A1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | DNASE1, RNASEH1, FEN1 | ALDH1A1 1635/4885RAB9A 2621/4885MAPT 1351/4885 |
| US-20210205275-A1 | NEUROPROTECTIVE COMPOSITIONS AND METHODS OF USING THE SAME | GAP43, NLN, SMN1; SMN2 | ALDH1A1 1731/4885RAB9A 2420/4885MAPT 24/4885 |
| US-11453663-B2 | Substituted propanamides as inhibitors of nucleases | DNASE1, RNASEH1, FEN1 | ALDH1A1 1635/4885RAB9A 2621/4885MAPT 1351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.