Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748600 | 0.91 | KMT2A (0.41) | KMT2AMAPTMAPK1NPC1MEN1 | |
| SCHEMBL9747406 | 0.85 | MAPT (0.37) | KMT2AMAPTMAPK1HTTNPC1 | |
| SCHEMBL9747889 | 0.81 | AKR1C3 (0.44) | KMT2AMAPTMAPK1HTTNPC1 | |
| SCHEMBL9748589 | 0.80 | KMT2A (0.39) | KMT2AMAPTMAPK1HTTNPC1 | |
| SCHEMBL9748582 | 0.75 | NR4A1 (0.44) | KMT2AMAPTMAPK1MEN1PGR | |
| SCHEMBL10949243 | 0.72 | KMT2A (0.37) | KMT2AMAPTHTTNPC1MEN1 | |
| SCHEMBL9651529 | 0.70 | PGR (0.45) | KMT2AMEN1PGRTP53KDM4E | |
| SCHEMBL10949720 | 0.68 | ALDH1A1 (0.34) | KMT2AMAPTMEN1TP53LMNA | |
| SCHEMBL28381581 | 0.68 | AKR1C3 (0.41) | KMT2AMAPTMAPK1HTTNPC1 | |
| SCHEMBL29362984 | 0.66 | MAPT (0.50) | KMT2AMAPTMAPK1HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | disclosed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | disclosed |