Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748692 | 0.91 | KMT2A (0.39) | KMT2ANPC1MEN1PGRRAB9A | |
| SCHEMBL9748589 | 0.88 | KMT2A (0.39) | KMT2APOLBNR4A1NPC1MEN1 | |
| SCHEMBL9748582 | 0.84 | NR4A1 (0.44) | KMT2ANR4A1MEN1PGRRAB9A | |
| SCHEMBL9747406 | 0.75 | MAPT (0.37) | KMT2ANPC1MEN1RAB9AMAPT | |
| SCHEMBL10949243 | 0.75 | KMT2A (0.37) | KMT2ANPC1MEN1MAPTHPGD | |
| SCHEMBL9651529 | 0.73 | PGR (0.45) | KMT2APOLBNR4A1MEN1PGR | |
| SCHEMBL10949720 | 0.70 | ALDH1A1 (0.34) | KMT2AMEN1RAB9AMAPTALDH1A1 | |
| SCHEMBL9747889 | 0.70 | AKR1C3 (0.44) | KMT2ANPC1MEN1RAB9AMAPT | |
| SCHEMBL9747790 | 0.70 | PGR (0.42) | KMT2APOLBNPC1MEN1PGR | |
| SCHEMBL10693566 | 0.67 | SRD5A2 (0.41) | KMT2ANR4A1NPC1MAPTSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | disclosed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | disclosed |