Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748714 | 0.90 | MDM2 (0.50) | MDM2GRIA2CA12CA1CA2 | |
| SCHEMBL26065 | 0.84 | MDM2 (0.68) | MDM2 | |
| SCHEMBL2865019 | 0.83 | KDM6B (0.61) | GRIA2HIF1AIDO1CTBP2KDM6B | |
| SCHEMBL2862796 | 0.83 | KDM6B (0.61) | GRIA2HIF1AIDO1CTBP2KDM6B | |
| SCHEMBL10830281 | 0.83 | CTSV (0.49) | MDM2CTBP2 | |
| SCHEMBL11817958 | 0.83 | MDM2 (0.49) | MDM2GRIA2CA12CA1CA2 | |
| SCHEMBL9748476 | 0.81 | NR4A2 (0.62) | — | |
| SCHEMBL19369761 | 0.78 | GRIA2 (0.50) | GRIA2HIF1ACTBP2KDM6BENPP2 | |
| SCHEMBL10830284 | 0.76 | MDM2 (0.49) | MDM2OPRK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4833396 | 0.76 | CTBP2 (0.56) | CA12CA1CA2CA6CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120874-A | Process for the preparation of 5-hydroxydiprafenone and its acid addition salts | HELOPHARM W. PETRIK GMBH & CO. KG (DE) | 1992-06-09 | — | — | US | claimed |
| EP-0283540-B1 | PROCESS FOR THE PREPARATION OF 5-HYDROXYDIPRAPHENONE AND ITS SALTS WITH ACIDS | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1991-09-18 | — | — | EP | claimed |
| EP-0283540-A1 | Process for the preparation of 5-hydroxydipraphenone and its salts with acids | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1988-09-28 | — | — | EP | claimed |
| US-5120874-A | Process for the preparation of 5-hydroxydiprafenone and its acid addition salts | HELOPHARM W. PETRIK GMBH & CO. KG (DE) | 1992-06-09 | — | — | US | disclosed |
| EP-0283540-B1 | PROCESS FOR THE PREPARATION OF 5-HYDROXYDIPRAPHENONE AND ITS SALTS WITH ACIDS | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0283540-A1 | Process for the preparation of 5-hydroxydipraphenone and its salts with acids | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1988-09-28 | — | — | EP | disclosed |