SCHEMBL9748786

SCHEMBL9748786

O=C(O)CCc1ccc2ccccc2c1O

nearest known ligand 0.79

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C19 P33261 1/20 0.54
CYP1A1 P04798 1/20 0.53
CYP1B1 Q16678 1/20 0.53
LDHA P00338 1/20 0.51
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
GLA P06280 1/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.47
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27926016 0.92 CYP1A2 (0.60) CYP1A2CYP2D6CYP2C19CYP1A1CYP1B1
SCHEMBL9749184 0.89 CYP1A2 (0.57) CYP1A2CYP2D6CYP2C19CYP1A1CYP1B1
SCHEMBL18892727 0.85 MTNR1A (0.50) CYP1A1CYP1B1LDHA
SCHEMBL2992806 0.83 KDM4E (0.56) CYP1A2CYP2D6CYP2C19MEN1KMT2A
Hydrochloric Acid SCHEMBL11319694 0.82 TDP1 (0.65) CYP1A2MEN1KMT2AKDM4E
SCHEMBL4889688 0.82 TDP1 (0.65) LDHAKDM4EALDH1A1GLAGAA
Succinic Acid SCHEMBL9658515 0.82
SCHEMBL4269770 0.81 CYP1A2 (0.53) CYP1A2CYP2D6CYP2C19MEN1KMT2A
SCHEMBL5997308 0.81 CYP1A2 (0.53) CYP1A2CYP2D6CYP2C19CYP1A1CYP1B1
SCHEMBL1218835 0.80 TDP1 (0.67) CYP1A2MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0201071-B1 2-SUBSTITUTED-1-NAPHTHOLS AS 5-LIPOXYGENASE INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-03-04 EP claimed
EP-2684863-B1 IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT NAT UNIV CORP NAGOYA UNIV (JP) 2017-05-24 EP disclosed
EP-2684863-B1 IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT NAT UNIV CORP NAGOYA UNIV (JP) 2017-05-24 EP disclosed
US-9018394-B2 Method for producing aromatic compound having ring structure that includes nitrogen atom or oxygen atom NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-04-28 US disclosed
US-9018394-B2 Method for producing aromatic compound having ring structure that includes nitrogen atom or oxygen atom NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-04-28 US disclosed
US-9018394-B2 Method for producing aromatic compound having ring structure that includes nitrogen atom or oxygen atom NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-04-28 US disclosed
US-9000216-B2 Iodoarene derivative, method for manufacturing optically active spirolactone compound by using the same, and method for manufacturing optically active cycloadduct NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-04-07 US disclosed
US-9000216-B2 Iodoarene derivative, method for manufacturing optically active spirolactone compound by using the same, and method for manufacturing optically active cycloadduct NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-04-07 US disclosed
US-9000216-B2 Iodoarene derivative, method for manufacturing optically active spirolactone compound by using the same, and method for manufacturing optically active cycloadduct NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-04-07 US disclosed
US-9000216-B2 Iodoarene derivative, method for manufacturing optically active spirolactone compound by using the same, and method for manufacturing optically active cycloadduct NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-04-07 US disclosed
EP-2684863-A1 IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT National University Corporation Nagoya University (JP) 2014-01-15 EP disclosed
EP-2684863-A1 IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT National University Corporation Nagoya University (JP) 2014-01-15 EP disclosed
EP-2684863-A1 IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT National University Corporation Nagoya University (JP) 2014-01-15 EP disclosed
US-20130338371-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING RING STRUCTURE THAT INCLUDES NITROGEN ATOM OR OXYGEN ATOM NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2013-12-19 US disclosed
US-20130338364-A1 IODOARENE DERIVATIVE, METHOD FOR MANUFACTURING OPTICALLY ACTIVE SPIROLACTONE COMPOUND BY USING THE SAME, AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CYCLOADDUCT NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2013-12-19 US disclosed
US-20130338364-A1 IODOARENE DERIVATIVE, METHOD FOR MANUFACTURING OPTICALLY ACTIVE SPIROLACTONE COMPOUND BY USING THE SAME, AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CYCLOADDUCT NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2013-12-19 US disclosed
CN-103415501-A Iodoarene derivative, method for producing optically active spirolactone compound using same, and method for producing optically active cyclization adduct UNIV NAGOYA NAT UNIV CORP 2013-11-27 CN disclosed
CN-103415501-A Iodoarene derivative, method for producing optically active spirolactone compound using same, and method for producing optically active cyclization adduct UNIV NAGOYA NAT UNIV CORP 2013-11-27 CN disclosed
WO-2012121248-A1 IODOARENE DERIVATIVE, METHOD FOR PRODUCING OPTICALLY ACTIVE SPIROLACTONE COMPOUND USING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIZATION ADDUCT 国立大学法人名古屋大学 (JP) 2012-09-13 WO disclosed
WO-2012111449-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING RING STRUCTURE THAT INCLUDES NITROGEN ATOM OR OXYGEN ATOM 国立大学法人名古屋大学 (JP) 2012-08-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130338371-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING RING STRUCTURE THAT INCLUDES NITROGEN ATOM OR OXYGEN ATOM TH, AOC3, NOX3 CYP1A2 160/4885CYP2D6 708/4885CYP2C19 424/4885
US-20130338364-A1 IODOARENE DERIVATIVE, METHOD FOR MANUFACTURING OPTICALLY ACTIVE SPIROLACTONE COMPOUND BY USING THE SAME, AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CYCLOADDUCT ADRA1A, HIRA, REN CYP1A2 392/4885CYP2D6 289/4885CYP2C19 536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.