Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.46 |
| ▸ | RARB | P10826 | 4/20 | 0.46 |
| ▸ | RARG | P13631 | 4/20 | 0.46 |
| ▸ | RARA | P10276 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9746735 | 0.84 | RARB (0.63) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL9748144 | 0.81 | RARB (0.60) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL10544739 | 0.80 | RARB (0.48) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL9746239 | 0.78 | PTPN11 (0.48) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL9746813 | 0.78 | RARB (0.43) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL8522801 | 0.77 | RXRA (0.60) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL9822364 | 0.77 | RARB (0.42) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL10539902 | 0.73 | RXRA (0.45) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL10355822 | 0.72 | RXRA (0.56) | CYP26B1CYP26A1RARBRARGRARA | |
| SCHEMBL11462163 | 0.72 | PTGS1 (0.60) | PTGS1AKR1C3AKR1C2RXRANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |