Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2479673 | 0.79 | KDM4E (0.46) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL28042879 | 0.74 | CNR2 (0.49) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL16806037 | 0.74 | MAPK14 (0.45) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL29228137 | 0.74 | GABRG2 (0.44) | MAPK14ADORA1 | |
| SCHEMBL29839887 | 0.73 | TDP1 (0.46) | MAPK14MAPK10ADORA1ADORA2A | |
| SCHEMBL1999851 | 0.72 | ADORA1 (0.46) | MAPK14MAPK10ADORA1ADORA2A | |
| SCHEMBL12813116 | 0.72 | MAPK14 (0.42) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL28654207 | 0.72 | MAPK14 (0.42) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL11369579 | 0.72 | ADORA2A (0.56) | MAPK14PTGS2MAPK13MAPK12MAPK11 | |
| SCHEMBL4752099 | 0.71 | JAK3 (0.57) | MAPK14PTGS2MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510074-A1 | PORPHYRIN DERIVATIVES AND METALLOPORPHYRINS OPTIONALLY COUPLED WITH A BIOLOGICALLY ACTIVE MOLECULE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | CIS BIO INTERNATIONAL (FR) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991010667-A1 | PORPHYRIN DERIVATIVES AND METALLOPORPHYRINS OPTIONALLY COUPLED WITH A BIOLOGICALLY ACTIVE MOLECULE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | CIS BIO INTERNATIONAL (FR) | 1991-07-25 | — | — | WO | disclosed |