Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 8/20 | 0.50 |
| ▸ | RARB | P10826 | 8/20 | 0.50 |
| ▸ | RARG | P13631 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9747007 | 0.86 | RARA (0.62) | RARARARBRARGMEN1KMT2A | |
| SCHEMBL10959462 | 0.80 | RARA (0.68) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL8677671 | 0.80 | CYP3A4 (0.61) | RARARARBRARGMEN1KMT2A | |
| SCHEMBL3819796 | 0.79 | RARB (0.60) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL9748378 | 0.78 | FFAR1 (0.58) | CYP26A1CYP26B1CYP3A4 | |
| SCHEMBL5888067 | 0.77 | RARB (0.66) | RARARARBRARGMEN1KMT2A | |
| SCHEMBL9746767 | 0.77 | RARA (0.52) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL9746770 | 0.77 | RARA (0.52) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL22001408 | 0.77 | RARA (0.69) | RARARARBRARGMAPTMEN1 | |
| SCHEMBL8458958 | 0.75 | RXRA (0.69) | RARARARBRARGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |