Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HEXA | P06865 | 1/20 | 0.39 |
| ▸ | HEXB | P07686 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9748432 | 0.88 | CYP3A4 (0.49) | MEN1KMT2ACYP3A4KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL9749792 | 0.86 | ADRA1A (0.42) | MEN1KMT2A | |
| SCHEMBL6658857 | 0.83 | CYP3A4 (0.53) | MEN1KMT2ACYP3A4NPC1HEXA | |
| SCHEMBL9747909 | 0.83 | CYP3A4 (0.51) | CYP3A4RAB9A | |
| SCHEMBL9749448 | 0.83 | RAB9A (0.39) | CYP3A4LMNAALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL9748576 | 0.83 | ADRA1D (0.40) | KMT2AADRB2CYP3A4KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL10859438 | 0.82 | CYP3A4 (0.37) | KMT2ACYP3A4KDM4EALDH1A1RAB9A | |
| Oxalic Acid SCHEMBL7294755 | 0.82 | CYP3A4 (0.49) | MEN1KMT2ACYP3A4KDM4ELMNA | |
| Oxalic Acid SCHEMBL9747733 | 0.82 | CYP3A4 (0.49) | MEN1KMT2ACYP3A4KDM4EGAA | |
| Oxalic Acid SCHEMBL9748543 | 0.82 | CYP3A4 (0.47) | MEN1KMT2ACYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237573-B1 | NOVEL BENZOTHIAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4786635-A | THERAPEUTIC AGENTS FOR CIRCULATORY DISEASES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1988-11-22 | — | — | US | disclosed |
| EP-0237573-A1 | NOVEL BENZOTHIAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1987-09-23 | — | — | EP | disclosed |