SCHEMBL9749534

SCHEMBL9749534

Cc1nc(SCCC(=O)O)sc1C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.54
ALDH1A1 P00352 4/20 0.49
SMN1; SMN2 Q16637 4/20 0.49
HSD17B10 Q99714 3/20 0.49
TSHR P16473 3/20 0.49
HPGD P15428 2/20 0.49
POLB P06746 2/20 0.49
MAPK1 P28482 1/20 0.49
GAA P10253 2/20 0.47
KDM4E B2RXH2 4/20 0.46
TDP1 Q9NUW8 1/20 0.46
RAB9A P51151 3/20 0.40
CSNK2A2 P19784 4/20 0.39
CSNK2B P67870 4/20 0.39
CSNK2A1 P68400 4/20 0.39
PRNP P04156 1/20 0.38
MAPK10 P53779 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
NPC1 O15118 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9749375 0.92 ALDH1A1 (0.45) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR
SCHEMBL9749606 0.91 ALDH1A1 (0.44) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR
SCHEMBL9748472 0.83 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2HSD17B10TSHRHPGD
SCHEMBL2210099 0.81 ALDH1A1 (0.44) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR
SCHEMBL10694025 0.79 APEX1 (0.53) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR
SCHEMBL7026098 0.78 ALDH1A1 (0.41) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR
SCHEMBL8668228 0.77 ALDH1A1 (0.44) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR
SCHEMBL10360761 0.77 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2HSD17B10TSHRHPGD
SCHEMBL10968557 0.75 APEX1 (0.47) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR
SCHEMBL9749386 0.75 ALDH1A1 (0.44) APEX1ALDH1A1SMN1; SMN2HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0194572-B1 HETEROCYCLIC SULFIDES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1992-01-02 EP disclosed
US-4762848-A IMMUNE SYSTEM STIMULANTS, CYTOSTATIC AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1988-08-09 US disclosed
EP-0194572-A1 Heterocyclic sulfides, process for their preparation and Medicaments containing them HOECHST AKTIENGESELLSCHAFT (DE) 1986-09-17 EP disclosed