Sugi Predict

Sugi Predict / Compounds / Histidine

Histidine

Histidine

SCHEMBL9750900

CC(C)C[C@H](N)C(=O)OC(=O)[C@@H](N)CCC(N)=O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.34
▸ BLM P54132 1/20 0.34
▸ PMP22 Q01453 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SLC7A5 Q01650 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL10379721 0.98 ALOX15 (0.36) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL9750983 0.94 ALOX15 (0.34) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL10379722 0.91 ALOX15 (0.40) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL9750903 0.91 ALOX15 (0.40) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL9750989 0.88 ALOX15 (0.38) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL27806428 0.88 ALOX15 (0.38) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL27730526 0.85 BLM (0.47) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL14690884 0.85 GSR (0.33) SLC7A5
Histidine SCHEMBL14691270 0.85 GSR (0.33) SLC7A5
Histidine SCHEMBL21768802 0.85 GSR (0.37) ALOX15BLMPMP22KMT2ASLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0347435-A4 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS — 1991-11-21 — — EP claimed
EP-0347435-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-12-27 — — EP claimed
WO-1989001940-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-03-09 — — WO claimed
EP-0347435-A4 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS — 1991-11-21 — — EP disclosed
EP-0347435-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-12-27 — — EP disclosed
WO-1989001940-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-03-09 — — WO disclosed