Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751002 | 1.00 | HMGCR (0.56) | HMGCRABCB1POLBALDH1A1MAPT | |
| SCHEMBL9750954 | 0.87 | HMGCR (0.57) | HMGCRABCB1POLBALDH1A1MAPT | |
| SCHEMBL9750818 | 0.84 | HMGCR (0.59) | HMGCRABCB1POLBALDH1A1MAPT | |
| SCHEMBL9518353 | 0.84 | HMGCR (0.59) | HMGCRABCB1POLBALDH1A1MAPT | |
| SCHEMBL9750981 | 0.81 | HMGCR (0.53) | HMGCRABCB1ALDH1A1MAPTMEN1 | |
| SCHEMBL9518535 | 0.76 | HMGCR (0.54) | HMGCRABCB1PTGS2 | |
| SCHEMBL9750926 | 0.76 | HMGCR (0.54) | HMGCRABCB1PTGS2 | |
| SCHEMBL9521513 | 0.75 | HMGCR (0.55) | HMGCRPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL9750922 | 0.75 | HMGCR (0.55) | HMGCRPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL9756864 | 0.73 | HMGCR (0.38) | HMGCRALDH1A1MEN1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |