Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750818 | 1.00 | HMGCR (0.59) | HMGCRPOLBALDH1A1MAPTABCB1 | |
| SCHEMBL9750837 | 0.88 | HMGCR (0.58) | HMGCRPOLBALDH1A1MAPTABCB1 | |
| SCHEMBL9751007 | 0.84 | HMGCR (0.56) | HMGCRPOLBALDH1A1MAPTABCB1 | |
| SCHEMBL9751002 | 0.84 | HMGCR (0.56) | HMGCRPOLBALDH1A1MAPTABCB1 | |
| SCHEMBL8846389 | 0.83 | HMGCR (0.55) | HMGCRALDH1A1MAPTABCB1KDM4E | |
| SCHEMBL9518437 | 0.80 | HMGCR (0.56) | HMGCRPTGS2 | |
| SCHEMBL9750945 | 0.80 | HMGCR (0.56) | HMGCRPTGS2 | |
| SCHEMBL9756726 | 0.76 | PTGS2 (0.39) | HMGCRALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL9756723 | 0.76 | PTGS2 (0.39) | HMGCRALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL9750852 | 0.76 | HMGCR (0.53) | HMGCRALDH1A1MAPTABCB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239306-B1 | TETRAHYDROCARBAZOLE ESTERS | MERCK FROSST CANADA INC. (CA) | 1993-06-02 | — | — | EP | claimed |
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |