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Arginine

Arginine

SCHEMBL9751283

CSCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)OC(=O)[C@@H](N)CCCCN.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ APLNR P35414 2/20 0.33
▸ PTH1R Q03431 3/20 0.32
▸ GLP1R P43220 7/20 0.32
▸ CTSL P07711 3/20 0.32
▸ CTSS P25774 3/20 0.32
▸ CTSK P43235 3/20 0.32
▸ SCTR P47872 1/20 0.32
▸ CTSH P09668 1/20 0.32
▸ GCGR P47871 1/20 0.31
▸ KEAP1 Q14145 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL11480224 0.85 GLP1R (0.31) GLP1RSCTRGCGR
Arginine SCHEMBL27730473 0.84 GLP1R (0.34) GLP1RSCTRGCGR
Arginine SCHEMBL27551617 0.84 APLNR (0.38) APLNRPTH1RGLP1RSCTRGCGR
Arginine SCHEMBL8314691 0.83 GSR (0.38) —
Arginine SCHEMBL28894222 0.82 APLNR (0.36) APLNRPTH1RGLP1RSCTRGCGR
Arginine SCHEMBL28894087 0.82 APLNR (0.36) APLNRPTH1RGLP1RSCTRGCGR
Arginine SCHEMBL23362144 0.81 FNTA (0.37) APLNRCTSLCTSSCTSKCTSH
Arginine SCHEMBL8512347 0.81 FNTA (0.37) APLNRCTSLCTSSCTSKCTSH
Arginine SCHEMBL8528151 0.81 GSR (0.36) APLNRGLP1RSCTR
Arginine SCHEMBL8528150 0.81 GSR (0.36) APLNRGLP1RSCTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0411018-A4 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES — 1991-08-21 — — EP disclosed
EP-0411018-A1 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES. DU PONT (US) 1991-02-06 — — EP disclosed
WO-1989010565-A1 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-11-02 — — WO disclosed