Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752977 | 0.90 | TP53 (0.34) | TP53MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9752975 | 0.90 | TP53 (0.34) | TP53MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9752941 | 0.89 | ALDH1A1 (0.35) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL27347534 | 0.82 | RORC (0.37) | TP53MEN1KMT2AMAPK14HSD11B1 | |
| SCHEMBL9753321 | 0.82 | MAPK14 (0.44) | KMT2AMAPK14ALDH1A1EGFRRAF1 | |
| SCHEMBL9753419 | 0.80 | GRM2 (0.36) | TP53MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9753040 | 0.80 | PTGS2 (0.36) | MAPK14ALDH1A1SPREGFRADORA2A | |
| SCHEMBL9753670 | 0.79 | HMGCR (0.34) | CNR1CNR2ADORA3 | |
| SCHEMBL9753663 | 0.79 | HMGCR (0.34) | CNR1CNR2ADORA3 | |
| SCHEMBL9753413 | 0.79 | HMGCR (0.44) | ALDH1A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |