Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16993537 | 0.85 | HTT (0.49) | HTTOPRM1OPRK1OPRL1ALOX15 | |
| SCHEMBL14379102 | 0.82 | OPRM1 (0.51) | HTTOPRM1OPRK1OPRL1HTR2C | |
| SCHEMBL9753142 | 0.82 | HTT (0.44) | HTTALOX15ALDH1A1 | |
| SCHEMBL3695589 | 0.77 | ALDH1A1 (0.44) | HTTALDH1A1 | |
| SCHEMBL3695590 | 0.77 | ALDH1A1 (0.44) | HTTALDH1A1 | |
| SCHEMBL30249996 | 0.77 | ALDH1A1 (0.46) | HTTALDH1A1 | |
| SCHEMBL5329580 | 0.76 | GAA (0.44) | OPRM1OPRK1OPRL1 | |
| SCHEMBL3634623 | 0.74 | ATM (0.35) | HTR2CTMEM97SIGMAR1 | |
| SCHEMBL3634626 | 0.74 | ATM (0.35) | HTR2CTMEM97SIGMAR1 | |
| SCHEMBL11475738 | 0.73 | TRPA1 (0.44) | OPRM1OPRK1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991007378-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-05-30 | — | — | WO | disclosed |