Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | DPP4 | P27487 | 5/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859669 | 0.76 | NOS2 (0.46) | ELANENOS2NOS3NOS1DPP4 | |
| SCHEMBL995604 | 0.76 | NOS2 (0.46) | ELANENOS2NOS3NOS1DPP4 | |
| SCHEMBL146828 | 0.76 | NOS2 (0.46) | ELANENOS2NOS3NOS1DPP4 | |
| SCHEMBL17503226 | 0.75 | NOS2 (0.42) | ELANENOS2NOS3NOS1CYP1A2 | |
| SCHEMBL252316 | 0.74 | DHODH (0.38) | — | |
| SCHEMBL383987 | 0.74 | ELANE (0.48) | ELANECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28789391 | 0.74 | ELANE (0.48) | ELANECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL21385077 | 0.73 | ELANE (0.47) | ELANECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9737609 | 0.73 | NOS2 (0.43) | ELANENOS2NOS3NOS1DPP4 | |
| SCHEMBL6281715 | 0.72 | KDM4E (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |