Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | PGK2 | P07205 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753412 | 0.75 | PGK1 (0.44) | PGK1PGK2SMN1; SMN2KMT2A | |
| SCHEMBL2088060 | 0.72 | NOS3 (0.54) | NOS1NOS2NOS3NPC1NCF1 | |
| SCHEMBL8607236 | 0.72 | NOS2 (0.37) | NOS1NOS2NOS3NPC1BACE1 | |
| SCHEMBL8607235 | 0.71 | NOS2 (0.38) | NOS1NOS2NOS3NPC1BACE1 | |
| SCHEMBL9753883 | 0.70 | SCN2A (0.43) | PGK1PGK2NPC1KDM4EALDH1A1 | |
| SCHEMBL5798610 | 0.70 | PGK1 (0.55) | PGK1PGK2KDM4EALDH1A1GAA | |
| SCHEMBL9104973 | 0.69 | NCF1 (0.51) | PGK1PGK2NCF1SMN1; SMN2KDM4E | |
| SCHEMBL23580818 | 0.68 | CALM1 (0.53) | PGK1PGK2NOS2BACE1THRB | |
| SCHEMBL2637242 | 0.68 | PGK1 (0.49) | PGK1PGK2 | |
| SCHEMBL5059411 | 0.67 | TSHR (0.38) | SMN1; SMN2ALDH1A1MAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |