Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469355 | 0.84 | KMT2A (0.51) | DHODHKMT2ABRD4RAB9ASMN1; SMN2 | |
| SCHEMBL4690949 | 0.83 | GRM4 (0.45) | DHODHKMT2ABRD4CYP1A2CYP2C9 | |
| SCHEMBL9753940 | 0.80 | BRD4 (0.48) | DHODHKMT2ABRD4RAB9ASMN1; SMN2 | |
| SCHEMBL9363596 | 0.73 | CYP1A2 (0.60) | KMT2ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11598546 | 0.72 | L3MBTL1 (0.42) | KMT2ACYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL12478330 | 0.71 | DHODH (0.71) | DHODHKMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL18338084 | 0.68 | KMT2A (0.58) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12478383 | 0.65 | SMN1; SMN2 (0.58) | DHODHKMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9631014 | 0.65 | ALDH1A1 (0.69) | RAB9ANPC1ALDH1A1THRBMAPK1 | |
| SCHEMBL11091368 | 0.64 | CYP1A2 (0.56) | KMT2ACYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018902-A1 | SUBSTITUTED 1-H-PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDES | SCHERING CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |
| US-5023265-A | Antiinflammatory agent; inhibits both 5-lipoxygenase and cyclooxygenase; rheumatoid arthritis, bursitis, tendonitis, gout; side effect reduction | SCHERING CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |