Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HLA-A | P04439 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753940 | 0.90 | BRD4 (0.48) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL4690949 | 0.88 | GRM4 (0.45) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL9754131 | 0.84 | DHODH (0.42) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL9469995 | 0.79 | RAB9A (0.55) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL9402422 | 0.78 | RAB9A (0.57) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL11598545 | 0.75 | MAPT (0.47) | KMT2AMEN1RAB9ASMN1; SMN2METAP2 | |
| Toluene SCHEMBL27877192 | 0.75 | RAB9A (0.48) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL11598546 | 0.72 | L3MBTL1 (0.42) | KMT2AMEN1RAB9ASMN1; SMN2METAP2 | |
| SCHEMBL9470451 | 0.72 | DHODH (0.51) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL9837351 | 0.71 | RAB9A (0.57) | KMT2AMEN1RAB9ADHODHSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |