Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754025 | 0.81 | ALOX5 (0.43) | PTGDR2ALOX5PTGS1PTGS2LMNA | |
| SCHEMBL9803529 | 0.81 | ALOX5 (0.43) | PTGDR2ALOX5PTGS1PTGS2LMNA | |
| SCHEMBL9803910 | 0.78 | PTGS1 (0.40) | PTGDR2ALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL9803550 | 0.75 | PTGDR2 (0.38) | PTGDR2ALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL9754195 | 0.73 | ALOX5 (0.46) | PTGDR2ALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL9754292 | 0.72 | ALOX5 (0.49) | PTGDR2ALOX5ALOX5APPTGS2 | |
| SCHEMBL9754095 | 0.70 | LMNA (0.43) | PTGDR2S1PR1ALOX5PTGS1PTGS2 | |
| SCHEMBL9754000 | 0.69 | ALOX5 (0.46) | S1PR1ALOX5ALOX5APS1PR3PTGS1 | |
| SCHEMBL9754341 | 0.69 | FBP1 (0.35) | ALOX5FBP1PTGS1PTGS2LMNA | |
| SCHEMBL9803881 | 0.68 | ALOX5 (0.33) | PTGDR2ALOX5ALOX5APPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | claimed |
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |