Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754195 | 0.88 | ALOX5 (0.46) | ALOX5CYP17A1ALOX5APPTGDR2PTGS2 | |
| SCHEMBL9754025 | 0.88 | ALOX5 (0.43) | ALOX5PTGDR2PTGS2 | |
| SCHEMBL9803529 | 0.86 | ALOX5 (0.43) | ALOX5PTGDR2PTGS2 | |
| SCHEMBL9754095 | 0.85 | LMNA (0.43) | ALOX5PTGDR2CYP1A2CYP2C19PTGS2 | |
| SCHEMBL9803803 | 0.79 | COPS5 (0.46) | ALOX5APCYP1A2PTGS2 | |
| SCHEMBL9754341 | 0.77 | FBP1 (0.35) | ALOX5FFAR1PTGS2 | |
| SCHEMBL9803532 | 0.77 | LMNA (0.35) | ALOX5FFAR1PTGS2 | |
| SCHEMBL9754000 | 0.76 | ALOX5 (0.46) | ALOX5ALOX5APPTGS2 | |
| SCHEMBL9803536 | 0.75 | PTGS1 (0.33) | ALOX5CYP17A1ALOX5APPTGS2 | |
| SCHEMBL9803773 | 0.75 | PTGS1 (0.38) | ALOX5PTGDR2PPARGPPARAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | claimed |
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |