Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754002 | 0.88 | ALOX5 (0.47) | ALOX5PTGS2DHODHKMT2A | |
| SCHEMBL9754030 | 0.86 | ALOX5 (0.44) | ALOX5PTGS2KMT2A | |
| SCHEMBL9754000 | 0.79 | ALOX5 (0.46) | ALOX5PTGS2 | |
| SCHEMBL9754025 | 0.77 | ALOX5 (0.43) | ALOX5PTGDR2PTGS2 | |
| SCHEMBL9803529 | 0.76 | ALOX5 (0.43) | ALOX5PTGDR2PTGS2 | |
| SCHEMBL6546976 | 0.72 | CALM1 (0.57) | ALOX5PTGS2 | |
| SCHEMBL22455579 | 0.71 | HPGD (0.43) | KDM4EDHODHMAPTHTTKMT2A | |
| SCHEMBL22455603 | 0.71 | HDAC6 (0.43) | KDM4EDHODHMAPTHTTKMT2A | |
| Isobutylbenzene SCHEMBL363626 | 0.70 | TAAR1 (0.61) | ALOX5PTGS2 | |
| SCHEMBL23954137 | 0.69 | ADORA3 (0.45) | ALOX5PTGDR2DHODHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | claimed |
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |