Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 13/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATF1 | P18846 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539254 | 0.90 | RAB9A (0.50) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL8808399 | 0.88 | RAB9A (0.51) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL3049960 | 0.87 | PDK1 (0.52) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL9754181 | 0.85 | NR1H4 (0.43) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL27323811 | 0.79 | LMNA (0.41) | RAB9AGAATSHR | |
| SCHEMBL5071880 | 0.72 | RAB9A (0.44) | RAB9ATSHR | |
| SCHEMBL9392594 | 0.72 | KMT2A (0.52) | RAB9A | |
| SCHEMBL5071947 | 0.71 | NPC1 (0.55) | RAB9A | |
| SCHEMBL8810187 | 0.70 | TSHR (0.48) | RAB9AGAATSHR | |
| SCHEMBL3059654 | 0.70 | GAA (0.50) | PDK1PDK2PDK4PDK3ATF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991017748-A1 | ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-28 | — | — | WO | disclosed |