Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756864 | 1.00 | HMGCR (0.38) | HMGCRMEN1KMT2APTGS2PTGS1 | |
| SCHEMBL9764105 | 0.88 | MEN1 (0.39) | HMGCRMEN1KMT2APTGS2PTGS1 | |
| SCHEMBL9750902 | 0.79 | HMGCR (0.46) | HMGCRMEN1KMT2APTGS2KDM4E | |
| SCHEMBL9750899 | 0.79 | HMGCR (0.46) | HMGCRMEN1KMT2APTGS2KDM4E | |
| SCHEMBL9756748 | 0.78 | HMGCR (0.48) | HMGCR | |
| SCHEMBL9756747 | 0.78 | HMGCR (0.48) | HMGCR | |
| SCHEMBL9521513 | 0.77 | HMGCR (0.55) | HMGCRMEN1KMT2APTGS2PTGS1 | |
| SCHEMBL9750922 | 0.77 | HMGCR (0.55) | HMGCRMEN1KMT2APTGS2PTGS1 | |
| SCHEMBL10691696 | 0.75 | ALDH1A1 (0.36) | HMGCRMEN1KMT2ALMNAKDM4E | |
| SCHEMBL9756785 | 0.75 | HMGCR (0.56) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992462-A | Inhibitor of HMG-CoA reductase | BAYER AKTIENGESELLSCHAFT (DE) | 1991-02-12 | — | — | US | disclosed |