Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 3/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | GRM5 | P41594 | 7/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971923 | 0.82 | CHRM2 (0.36) | SCN1ASCN8ACHRM2CHRM1GRM5 | |
| SCHEMBL973236 | 0.80 | GRM5 (0.39) | SCN1ASCN8AGRM5ADORA3 | |
| SCHEMBL2852667 | 0.79 | SIGMAR1 (0.44) | SCN1ASCN8AGRM5 | |
| SCHEMBL975924 | 0.78 | TRPM8 (0.39) | SCN1ASCN8ACHRM2GRM5 | |
| SCHEMBL4701149 | 0.77 | GRIN2B (0.41) | SCN1ASCN8AGRM5 | |
| SCHEMBL972486 | 0.75 | USP30 (0.39) | SCN1ASCN8ACHRM2CHRM1GRM5 | |
| SCHEMBL3160433 | 0.73 | GRM5 (0.40) | CHRM2CHRM1GRM5 | |
| SCHEMBL8234256 | 0.72 | PKM (0.45) | GRM5CYP2D6 | |
| SCHEMBL3156188 | 0.70 | CHRM2 (0.36) | CHRM2CHRM1GRM5 | |
| SCHEMBL972450 | 0.66 | GRM5 (0.39) | GRM5ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871999-B2 | Substituted thiazoles and their use for producing drugs | GRUENENTHAL GMBH (DE) | 2011-01-18 | — | — | US | claimed |
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2007079960-A9 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |
| EP-1968957-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007079960-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |