Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 9/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 9/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971923 | 0.93 | CHRM2 (0.36) | USP30SCN1ASCN8ACHRM2CHRM1 | |
| SCHEMBL972487 | 0.81 | GRM5 (0.39) | USP30GRM5 | |
| SCHEMBL971924 | 0.78 | GRM5 (0.40) | USP30GRM5 | |
| SCHEMBL975937 | 0.75 | SCN1A (0.37) | SCN1ASCN8ACHRM2CHRM1GRM5 | |
| SCHEMBL8234230 | 0.73 | ALDH1A1 (0.47) | USP30 | |
| SCHEMBL2852667 | 0.71 | SIGMAR1 (0.44) | USP30EBPSIGMAR1SCN1ASCN8A | |
| SCHEMBL8228125 | 0.68 | PKM (0.43) | GRM5 | |
| SCHEMBL975924 | 0.66 | TRPM8 (0.39) | USP30EBPSIGMAR1SCN1ASCN8A | |
| SCHEMBL973631 | 0.65 | GRM5 (0.40) | GRM5 | |
| SCHEMBL4701149 | 0.64 | GRIN2B (0.41) | EBPSIGMAR1SCN1ASCN8AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871999-B2 | Substituted thiazoles and their use for producing drugs | GRUENENTHAL GMBH (DE) | 2011-01-18 | — | — | US | claimed |
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2007079960-A9 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |
| EP-1968957-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007079960-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |