Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760074 | 0.81 | DRD2 (0.55) | F10ALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL8637204 | 0.79 | HRH3 (0.44) | F10SMN1; SMN2F2 | |
| SCHEMBL5214498 | 0.77 | BRD4 (0.53) | ALDH1A1KDM4ESMN1; SMN2HSD17B10BRD4 | |
| SCHEMBL1475102 | 0.77 | TGFBR1 (0.56) | ALDH1A1KDM4EBRD4POLB | |
| Hydrochloric Acid SCHEMBL1474917 | 0.76 | BRD4 (0.52) | ALDH1A1KDM4ESMN1; SMN2HSD17B10BRD4 | |
| SCHEMBL1475451 | 0.76 | ABCB11 (0.46) | ALDH1A1BRD4MRGPRX1 | |
| SCHEMBL5634334 | 0.76 | F10 (0.47) | F10 | |
| SCHEMBL1475864 | 0.75 | ABCB11 (0.43) | ALDH1A1KDM4EBRD4MRGPRX1 | |
| SCHEMBL7406978 | 0.75 | HDAC3 (0.55) | — | |
| SCHEMBL5633263 | 0.74 | F10 (0.55) | F10ALDH1A1KMT2APOLBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |