Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 10/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9761791 | 0.83 | LMNA (0.59) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15244777 | 0.79 | LMNA (0.66) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18885590 | 0.79 | KDM4E (0.44) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL152719 | 0.77 | TNF (0.65) | LMNATP53ALDH1A1MEN1CYP1A2 | |
| SCHEMBL18885589 | 0.76 | TP53 (0.47) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9537927 | 0.76 | LMNA (0.55) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9539209 | 0.76 | LMNA (0.55) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7833959 | 0.75 | LMNA (0.60) | LMNABRD4ENPP2TP53MEN1 | |
| SCHEMBL9761903 | 0.74 | PDE4A (0.50) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15244750 | 0.73 | TAAR1 (0.48) | LMNAPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023256-A | Antihistamines | DOMPE FARMACEUTICI S.P.A. (IT) | 1991-06-11 | — | — | US | disclosed |