Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760792 | 0.92 | POLB (0.51) | ACACBPOLBMAPTCYP2C9CYP2C19 | |
| SCHEMBL31225012 | 0.85 | MAPT (0.59) | ACACBPOLBMAPTCYP2C9CYP2C19 | |
| SCHEMBL7958424 | 0.83 | MAPT (0.44) | ACACBPOLBMAPTCYP2C9CYP2C19 | |
| SCHEMBL5634035 | 0.83 | MAPT (0.44) | ACACBPOLBMAPTCYP2C9CYP2C19 | |
| SCHEMBL7958334 | 0.83 | MAPT (0.44) | ACACBPOLBMAPTCYP2C9CYP2C19 | |
| SCHEMBL7956152 | 0.81 | ACACB (0.52) | ACACB | |
| SCHEMBL7956662 | 0.80 | ACACB (0.55) | ACACBHRH3 | |
| SCHEMBL7956861 | 0.80 | ACACB (0.51) | ACACB | |
| SCHEMBL7955313 | 0.78 | ACACB (0.49) | ACACB | |
| SCHEMBL7958655 | 0.78 | LIPG (0.50) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |