SCHEMBL976242

SCHEMBL976242

COC(=O)c1ccc2c(CN)c3ccccc3c(CN)c2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.54
KIF11 P52732 1/20 0.54
PARP1 P09874 1/20 0.50
GPR84 Q9NQS5 1/20 0.49
TSHR P16473 1/20 0.46
MAPT P10636 3/20 0.45
ALDH1A1 P00352 3/20 0.45
ATM Q13315 2/20 0.45
KDM4E B2RXH2 2/20 0.45
GAA P10253 2/20 0.45
HPGD P15428 2/20 0.45
GLA P06280 1/20 0.45
CASP1 P29466 1/20 0.45
CASP7 P55210 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA7 P43166 1/20 0.45
XDH P47989 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL974529 0.84 KIF11 (0.54) LOXL2KIF11PARP1GPR84TSHR
SCHEMBL14001411 0.83 KIF11 (0.52) LOXL2KIF11PARP1GPR84TSHR
SCHEMBL976725 0.77 KIF11 (0.59) KIF11PARP1GPR84TSHRMAPT
SCHEMBL10901105 0.76 KIF11 (0.55) KIF11PARP1GPR84TSHRMAPT
SCHEMBL30044523 0.76 KIF11 (0.58) KIF11PARP1GPR84TSHRMAPT
SCHEMBL27729823 0.76 KIF11 (0.58) KIF11PARP1GPR84TSHRMAPT
SCHEMBL609398 0.76 KIF11 (0.58) KIF11PARP1GPR84TSHRMAPT
SCHEMBL2527811 0.74 KIF11 (0.56) KIF11PARP1GPR84TSHRMAPT
SCHEMBL7936413 0.73 KIF11 (0.55) KIF11PARP1GPR84TSHRMAPT
SCHEMBL10899615 0.73 KIF11 (0.55) KIF11PARP1GPR84TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7873398-B2 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO KABUSHIKI KAISHA (JP) 2011-01-18 US disclosed
US-7524985-B2 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO KABUSHIKI KAISHA (JP) 2009-04-28 US disclosed
US-20080319288-A1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO KABUSHIKI KAISHA (JP) 2008-12-25 US disclosed
US-7388110-B2 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO KABUSHIKI KAISHA (JP) 2008-06-17 US disclosed
US-20080021236-A1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO KABUSHIKI KAISHA (JP) 2008-01-24 US disclosed
EP-1619229-B1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO CORP (JP) 2007-04-11 EP disclosed
US-20060020182-A1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO KABUSHIKI KAISHA 2006-01-26 US disclosed
EP-1619229-A1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor TERUMO KABUSHIKI KAISHA (JP) 2006-01-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080319288-A1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor ACMSD, QPCT, B3GNT2 LOXL2 4093/4885KIF11 4634/4885PARP1 2737/4885
US-20060020182-A1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor ACMSD, QPCT, B3GNT2 LOXL2 4027/4885KIF11 4648/4885PARP1 3236/4885
US-20080021236-A1 Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor ACMSD, QPCT, B3GNT2 LOXL2 4027/4885KIF11 4648/4885PARP1 3236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.