Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015707 | 0.78 | ALDH3A1 (0.47) | NPSR1MAPTAKR1B1AKR1C4AKR1C3 | |
| SCHEMBL13608501 | 0.78 | MEN1 (0.57) | NPSR1MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL4908494 | 0.78 | ALDH1A1 (0.54) | NPSR1MAPTPDE7AHTTALDH1A1 | |
| SCHEMBL29836965 | 0.78 | MEN1 (0.57) | NPSR1MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL29836966 | 0.78 | MEN1 (0.57) | NPSR1MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL16739563 | 0.77 | KCNMA1 (0.63) | NPSR1MAPTAKR1B1AKR1C4AKR1C3 | |
| SCHEMBL22535975 | 0.76 | CYP3A4 (0.55) | NPSR1MAPTPDE7AHTTALDH1A1 | |
| SCHEMBL11215556 | 0.76 | NPSR1 (0.62) | NPSR1MAPTPDE7AHTTALDH1A1 | |
| SCHEMBL10790188 | 0.76 | HTT (0.68) | NPSR1MAPTPDE7AHTTALDH1A1 | |
| SCHEMBL6296282 | 0.75 | NPC1 (0.52) | MAPTAKR1B1AKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297570-B1 | 2,2-BIS-(3-AMINOPHENYL)-HEXAFLUOROPROPANE DERIVATIVES AND PROCESS FOR THE PREPARATION OF 2,2-BIS-(3,4-DIAMINOPHENYL)-HEXAFLUOROPROPANE | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-05 | — | — | EP | disclosed |
| US-4922019-A | Derivatives of 2,2-bis-(3-aminophenyl)hexafluoropropane and process for the preparation of 2,2-bis-(3,4-diaminophenyl)hexafluoropropane | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-01 | — | — | US | disclosed |
| EP-0297570-A2 | 2,2-Bis-(3-aminophenyl)-hexafluoropropane derivatives and process for the preparation of 2,2-bis-(3,4-diaminophenyl)-hexafluoropropane | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-04 | — | — | EP | disclosed |