Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198859 | 0.82 | ALOX5 (0.50) | LMNAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4018145 | 0.80 | LMNA (0.56) | LMNAALDH1A1NPSR1TSHRMEN1 | |
| SCHEMBL27364470 | 0.78 | CCR6 (0.55) | LMNAALDH1A1NPSR1TSHRKMT2A | |
| SCHEMBL8060186 | 0.78 | SRD5A1 (0.54) | LMNAKDM4EALDH1A1NPSR1TSHR | |
| SCHEMBL825414 | 0.78 | LMNA (0.63) | LMNAKDM4EALDH1A1NPSR1TSHR | |
| Carbamic Acid SCHEMBL29254315 | 0.78 | CCR6 (0.51) | LMNAKDM4EALDH1A1NPSR1KMT2A | |
| SCHEMBL9278775 | 0.77 | ALDH1A1 (0.64) | LMNAALDH1A1NPSR1TSHRMEN1 | |
| SCHEMBL2182156 | 0.77 | LMNA (0.49) | LMNAKDM4EALDH1A1NPSR1TSHR | |
| SCHEMBL2182432 | 0.77 | LMNA (0.49) | LMNAKDM4EALDH1A1NPSR1TSHR | |
| SCHEMBL1386528 | 0.77 | LMNA (0.57) | LMNAKDM4EALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102863374-A | Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders | ARYX THERAPEUTICS | 2013-01-09 | — | — | CN | disclosed |
| CN-101258151-B | Process for the synthesis of stereoisomeric compounds useful in the treatment of gastrointestinal and central nervous system disorders and intermediates | ARYX THERAPEUTICS INC | 2012-10-10 | — | — | CN | disclosed |
| CN-101258151-A | Process for the synthesis of stereoisomeric compounds useful in the treatment of gastrointestinal and central nervous system disorders and intermediates | ARYX THERAPEUTICS INC (US) | 2008-09-03 | — | — | CN | disclosed |
| US-5057610-A | Oxidation, heat and radiation resistance | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0244355-B1 | COMPOSITIONS STABILIZED WITH SUBSTITUTED AMINOCARBAMATES, AND SUBSTITUTED AMINOCARBAMATES | CIBA-GEIGY AG (CH) | 1990-08-01 | — | — | EP | disclosed |
| US-4758614-A | Compositions stabilized with substituted amino carbamates | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0244355-A2 | Compositions stabilized with substituted aminocarbamates, and substituted aminocarbamates | CIBA-GEIGY AG (CH) | 1987-11-04 | — | — | EP | disclosed |