Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 3/20 | 0.50 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | BAX | Q07812 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL4275227 | 0.95 | LTA4H (0.63) | LTA4HTSHRSOS1CA1CA2 | |
| Diphenylether SCHEMBL4275226 | 0.95 | LTA4H (0.63) | LTA4HTSHRSOS1CA1CA2 | |
| Diphenylether SCHEMBL29236470 | 0.83 | SOS1 (0.55) | LTA4HTSHRSOS1CA1CA2 | |
| Diphenylether SCHEMBL387430 | 0.81 | LTA4H (0.67) | LTA4HTSHRSOS1CA1CA2 | |
| Diphenylether SCHEMBL8662108 | 0.81 | LTA4H (0.67) | LTA4HTSHRSOS1CA1CA2 | |
| Diphenylether SCHEMBL130202 | 0.81 | LTA4H (0.67) | LTA4HTSHRSOS1CA1CA2 | |
| Diphenylether SCHEMBL28109377 | 0.81 | CA1 (0.71) | LTA4HTSHRSOS1CA1CA2 | |
| SCHEMBL17559302 | 0.80 | HTT (0.81) | LTA4HTSHRSOS1CA1CA2 | |
| SCHEMBL6123058 | 0.80 | HTT (0.81) | LTA4HTSHRSOS1CA1CA2 | |
| SCHEMBL146566 | 0.80 | HTT (0.81) | LTA4HTSHRSOS1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045109-A | Thiolcarbamate compound, emulsion with nonionic and anionic surfactants | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-09-03 | — | — | US | disclosed |