Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 3/20 | 0.30 |
| ▸ | ACHE | P22303 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764279 | 0.86 | NR1H3 (0.35) | NR1H3BCHEACHEKDM4E | |
| SCHEMBL9764538 | 0.84 | HPGD (0.35) | NR1H3BCHEACHEKDM4E | |
| SCHEMBL9764422 | 0.83 | LTA4H (0.37) | KCNH2KDM4E | |
| SCHEMBL9319139 | 0.82 | MAOB (0.38) | NR1H3 | |
| SCHEMBL10466615 | 0.81 | NR1H3 (0.34) | KCNH2NR1H3BCHEACHEKDM4E | |
| SCHEMBL10466515 | 0.80 | SPPL2A (0.35) | KCNH2PSEN1PSEN2SPPL2AAPH1B | |
| SCHEMBL10466852 | 0.80 | KCNH2 (0.36) | KCNH2PSEN1PSEN2SPPL2AAPH1B | |
| SCHEMBL9764569 | 0.80 | SNCA (0.38) | — | |
| SCHEMBL10468372 | 0.80 | NR1H3 (0.33) | NR1H3BCHEACHEKDM4E | |
| SCHEMBL10466337 | 0.79 | NR1H3 (0.31) | NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |