Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.50 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.48 |
| ▸ | JAK2 known ✓ | O60674 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | HTR1D | P28221 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9764595 | 1.00 | HTR6 (0.51) | HTR6HTR1DKDM4EALDH1A1HSD17B10 | |
| Maleic Acid SCHEMBL10513423 | 0.81 | SLC6A4 (0.60) | — | |
| Fumaric Acid SCHEMBL10513433 | 0.81 | SLC6A4 (0.60) | — | |
| SCHEMBL13533314 | 0.79 | HTR6 (0.63) | HTR6HTR1DKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6631360 | 0.77 | HTR6 (0.60) | HTR6HTR1DKDM4EALDH1A1HSD17B10 | |
| Fumaric Acid SCHEMBL7481167 | 0.73 | HTR6 (0.44) | HTR6HTR1DKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3836149 | 0.72 | HTR6 (0.67) | HTR6HTR1DKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1675799 | 0.72 | HTR6 (0.67) | HTR6HTR1DKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6631651 | 0.72 | KDM4E (0.70) | HTR6HTR1DKDM4EALDH1A1HSD17B10 | |
| Fumaric Acid SCHEMBL7481164 | 0.72 | HTR6 (0.46) | HTR6HTR1DKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066660-A | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |