Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.60 |
| ▸ | NOS3 | P29474 | 2/20 | 0.56 |
| ▸ | NOS1 | P29475 | 2/20 | 0.56 |
| ▸ | NOS2 | P35228 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10513433 | 1.00 | SLC6A4 (0.60) | SLC6A4NOS3NOS1NOS2 | |
| Fumaric Acid SCHEMBL9764595 | 0.81 | HTR6 (0.51) | — | |
| Maleic Acid SCHEMBL9764590 | 0.81 | HTR6 (0.51) | — | |
| SCHEMBL3379399 | 0.80 | SLC6A4 (0.71) | SLC6A4 | |
| SCHEMBL7205038 | 0.80 | SLC6A4 (0.65) | SLC6A4 | |
| Fumaric Acid SCHEMBL7483151 | 0.79 | NOS3 (0.62) | SLC6A4NOS3NOS1 | |
| Fumaric Acid SCHEMBL7483149 | 0.79 | NOS3 (0.62) | SLC6A4NOS3NOS1 | |
| SCHEMBL7209936 | 0.79 | SLC6A4 (0.67) | SLC6A4 | |
| Fumaric Acid SCHEMBL8870626 | 0.79 | SLC6A4 (0.64) | SLC6A4NOS3NOS1 | |
| Fumaric Acid SCHEMBL8869522 | 0.79 | SLC6A4 (0.57) | SLC6A4NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |