SCHEMBL9764749

SCHEMBL9764749

O=C(Cl)c1ccc(OC2(Oc3ccc(C(=O)Cl)cc3)C(F)(F)C(F)(F)C2(F)F)cc1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
HPGD P15428 2/20 0.31
KMT2A Q03164 2/20 0.31
PARP15 Q460N3 1/20 0.31
PARP14 Q460N5 1/20 0.31
PARP10 Q53GL7 1/20 0.31
PARP16 Q8N5Y8 1/20 0.31
PARP11 Q9NR21 1/20 0.31
PARP4 Q9UKK3 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31
GSK3B P49841 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9171497 0.83 ALDH1A1 (0.37) ALDH1A1HPGDKMT2APARP15PARP14
SCHEMBL9806635 0.75 ALDH1A1 (0.32) ALDH1A1
SCHEMBL9751693 0.74 LMNA (0.52) ALDH1A1HPGDKMT2AMAPTRAB9A
SCHEMBL9751696 0.74 ESR2 (0.44) ALDH1A1HPGDKMT2APARP10MAPT
SCHEMBL9366572 0.73 PARP10 (0.38) ALDH1A1HPGDKMT2APARP15PARP14
SCHEMBL9806641 0.73 ALDH1A1 (0.35) ALDH1A1HPGDKMT2APARP15PARP14
SCHEMBL9848307 0.71 ALDH1A1 (0.39) ALDH1A1
SCHEMBL272345 0.71 PARP10 (0.58) ALDH1A1HPGDKMT2APARP15PARP14
SCHEMBL9786679 0.71 PARP10 (0.58) ALDH1A1HPGDKMT2APARP15PARP14
SCHEMBL20587670 0.69 ALDH1A1 (0.59) ALDH1A1HPGDMAPTCES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0428708-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015082-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed