Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764840 | 0.82 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL10928021 | 0.76 | ALOX5 (0.36) | ALOX5SYKCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL20889266 | 0.74 | ALOX5 (0.42) | ALOX5SYKCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL19682602 | 0.74 | ALOX5 (0.42) | ALOX5SYKCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9764889 | 0.73 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL10927783 | 0.72 | ALOX5 (0.35) | ALOX5SYKCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL10367027 | 0.71 | CXCL8 (0.41) | ALOX5CSNK2A2CSNK2BCSNK2A1 | |
| Hydrochloric Acid SCHEMBL10929080 | 0.71 | ALOX5 (0.35) | ALOX5SYKOPRM1OPRK1 | |
| SCHEMBL20509484 | 0.69 | CYP1A2 (0.41) | ALOX5SYK | |
| SCHEMBL29985513 | 0.69 | CYP1A2 (0.41) | ALOX5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |