Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764925 | 0.81 | ALOX5 (0.45) | ALOX5MAOB | |
| SCHEMBL9764819 | 0.73 | ALOX5 (0.43) | ALOX5 | |
| SCHEMBL7250159 | 0.69 | CXCL8 (0.41) | KCNA3MAOAMAOBFTOMTNR1A | |
| SCHEMBL10561811 | 0.68 | ALOX5 (0.43) | ALOX5MAOB | |
| SCHEMBL4459839 | 0.68 | CYP1A2 (0.42) | KCNA3MAOAMAOBFTOEED | |
| SCHEMBL12261467 | 0.67 | HTR2C (0.40) | KCNA3MAOAMAOBFTOMTNR1A | |
| SCHEMBL19354174 | 0.67 | MAOA (0.42) | KCNA3MAOAMAOBFTOMTNR1A | |
| SCHEMBL9764845 | 0.67 | MAOB (0.42) | MAOB | |
| SCHEMBL827158 | 0.66 | ALDH1A1 (0.46) | MAOAMAOBFTOMTNR1AMTNR1B | |
| SCHEMBL30669447 | 0.66 | ALDH1A1 (0.46) | MAOAMAOBFTOMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |